Ferdinand Magellan's five-ship expedition departed Seville, beginning the voyage that would become the first circumnavigation of the globe.

Ferdinand Magellan departed Sanlúcar de Barrameda with five ships, beginning the expedition that became the first circumnavigation of the globe.

Hernán Cortés and his small Spanish force entered Tenochtitlan and met Aztec emperor Moctezuma II, beginning the conquest of the Aztec Empire.