English physician Richard Lower reports successful transfusion experiments between animals, laying groundwork for the science of transfusion medicine.

A small bakery fire on Pudding Lane spread into a blaze that destroyed most of medieval London, consuming 13,200 houses over four days.

After four days of devastation, firefighters and desperate Londoners finally halted the Great Fire's spread, having destroyed over 13,000 houses and 87 churches.

The Great Fire of London finally burned itself out after four days, having destroyed over 13,000 houses and reshaped the medieval city forever.